Angelina Jolie is winning acclaim and award nominations for her portrayal of O.G. opera diva Maria Callas in the movie Maria, which follows Callas through the last seven days of her life, with fuzzy flashbacks to her earlier days. It is the third and final film in a trilogy depicting iconic 20th-century women from Chilean director Pablo Larrain, following Jackie (2016) starring Natalie Portman as Jackie Kennedy and Spencer (2021) with Kristen Stewart as Princess Diana.
In Maria, Callas is shown taking Mandrax, a combination of the hypnotic sedative drug methaqualone (Quaaludes) and the anti-histamine/sedative diphenhydramine (Benadryl). Popular in Europe in the 70s, commercial production of Mandrax was halted in the mid-1980s due to its widespread abuse and addictiveness.
An imaginary young filmmaker whose name is Mandrax appears to interview Callas, setting up a conversation between her and the drug, or her hallucination while taking it. By this strange conceit Maria's life is revisited as she works on recovering her largely lost etherial singing voice just before dying.