"The Marijuana Conspiracy" and The Research Dodge

The Canadian film "The Marijuana Conspiracy," released in the US on 4/20, illustrates in part the absurdity and politicization of research into marijuana's effects. The film, based on a study that happened in 1972 in Toronto, begins with footage of politicians (all old, white men) railing against marijuana use. We then meet an old, white male addiction researcher downing a martini who hires an unscrupulous hippie-type researcher out for fame and fortune who recruits young women pot smokers for a study aimed at discovering marijuana's harms. 

The women were locked in a building for 98 days, with no escape to take a walk outside or see their friends or families, while being constantly observed by researchers. Even the joints they were given to smoke nightly couldn't counter the effects of this strange, unnatural setting and the film (and doubtlessly the study itself) devolves into melodrama. Like many rats put in a cage, the women were pointlessly overdosed with pot. Yet, they remained productive and experienced no ill effects, although some members of both the smoking group and the nonsmoking control groups had difficulty assimilating after their isolation. The results of the study were never publicized due to political reasons, and it took decades for Canada to finally legalize pot (the US still hasn't done so). 

Sex Differences In Pain Relief with Cannabis

Photos by Larry Utley of a bipolar woman experiencing pain relief with cannabis.
Her face is shown pre-treatment (left) and at 30 and 60 seconds after smoking.

Less than 10% of neurological and pharmacological research is conducted on females in the US, says Dr. Rebecca Craft of Washington State University. Her lab is working to help correct that imbalance, by studying the effects of THC on male and female rats.

Craft's lab took healthy rats, 10 males and 10 females, and dosed them every 15 minutes with THC. At each dosage level, researchers did two tests for acute pain: putting the rats’ tails in 122-degree water and measuring how quickly they pulled their tails out; and applying pressure to their paws and measuring at what level of pressure they retracted their paws. As expected, the analgesic effect of THC increased at higher levels in both sexes, but to a greater extent in females.

Researchers then did a nine-day experiment, injecting the rats twice daily with THC in an amount determined to produce 80% of maximal analgesia (a lesser amount for females). The pain experiments were then repeated, in order to study to what extent tolerance to THC’s pain-relieving effects had taken place. It took more THC to show a pain-relieving response in rats that had received chronic doses, and this effect was also more pronounced in females.

Taken together with a recent study showing that women using cannabis daily reported a higher incidence of “abuse related effects” than men,  Dr. Craft’s work has been reported as being cautionary for women using cannabis medicinally. However Dr. Craft says that it’s hard to relate results, or doses, between acute pain studies in rodents and chronic pain in humans. For example, the opposite effect is found for morphine: male rats are more susceptible to its acute effects and develop greater tolerance, but the same sex difference has not been found in humans.

It’s been theorized that the hormone estradiol in menstruating females is responsible for the observed differences in cannabinoid effects, possibly through the mechanism of beta-arrestin2, an intracellular signaling molecule that interacts with the CB1 cannabinoid receptor in the brain. But some studies Craft’s lab has been working on indicate that sex hormones aren’t responsible for sex differences in tolerance to THC’s pain-relieving effects, although they may have a role in its sedative effects. Also, in rats a different enzyme metabolizes THC into its main active metabolite 11-OH-THC in males and females, but in humans, the enzyme is the same for both sexes.

Dr. Rebecca Craft of WSU

Dr. Craft’s next study will be working with a chronic pain model in rats, mimicking the inflammatory pain of rheumatoid arthritis. Chronic pain models in rodents have also been developed for neuropathic pain of the type experienced by chemotherapy patients and diabetes sufferers.

The work is important: women are more likely to present with chronic pain issues, for diseases like fibromyalgia, IBS, MS and migraine as well as the depression that comes with pain. A new study shows women find cannabis more effective than other pain-treatment modalities.

More human research is needed, Dr. Craft stresses, and also more research on females in both human and animal studies. The NIH has recently announced it will require sex-balancing in upcoming studies. Craft is encouraged by NIDA’s recent pronouncement that the agency will be providing more cannabis for research. Her work is funded by a NIDA grant.

Pointing to these developments, and to the legalization of medical and recreational marijuana that is happening across the US, Craft predicts, “We will see an explosion of information in the coming decades.”

Why Take Marijuana (or Alcohol)? Researchers Want to Know

Maybe I'm just trying to make up for the bikini shot I posted last night (hey, it had pot leaves on it!) but I spent my Friday night wonkily reading results from some interesting research published in 1976, when marijuana was still spelled with an "h" (see above).

Researchers from Stanford University and the Veteran's Administration in Palo Alto put 220-item questionnaires into the mailboxes of an entering class of first-year law students and of medical students and house officers at the University hospital. The questionnaire asked respondents to rate each of 38 possible effects of marijuana or alcohol as a major reason to take it, a minor reason, not a reason, or having no effect. Forms were returned anonymously. The data gathered are based on the 51 respondents who used both marijuana and alcohol with a frequency of greater than once a month for some six-month period of their life. 

Ranked in order of the percentage who cited the effect as a major reason for taking the drug, marijuana’s top effect was “increases enjoyment of sights and sounds,” with 45% of respondents calling that a major reason for using it; this effect didn’t make the cut for alcohol users. The top reason for using alcohol was “increases my feeling of sociability,” which appears ninth in the rankings for marijuana.

Coming in at #2 for alcohol was “relieves anxiety or tension,” something not attributed to marijuana as a reason for use. For marijuana, “enables me to experience a different state of consciousness” was the #2 reason; for alcohol that was #6. “Makes me feel euphoric” earned large enough percentages to rank #3 on both lists.

The research was supported by a National Institute for Mental Health grant and the VA administration. It found that marijuana had several effects like, “enables me to think more creatively,” “enables me to get insight into myself,” and “provides philosophic or religious insights” which weren’t attributed to alcohol. "Marihuana is valued as a drug for experiencing and thinking about things in a new way," the authors wrote. "Since much of psychotherapy is based on helping people to achieve new perspectives and insights, marihuana might be considered as an aid for psychological problem solving and growth." 

While 17% of respondents said alcohol “makes me feel more attractive to others,” only 26% said alcohol “enhances sexual sensation” while 70% said marijuana did (as a major or minor reason). "When performance anxiety leads to male impotence or female frigidity, marihuana might enhance sexual sensation, permitting enough success to break out of the vicious circle of failure leading to anxiety leading to further failure." Take that, Viagra. (No bikini required.)  

SUBJECTIVE BENEFITS AND DRAWBACKS OF MARIHUANA AND ALCOHOL

Walton T. Roth

Jared R. Tinklenberg

Bert S. Kopell

Dept of Psychiatry and Behavioral Sciences

Stanford University

And

Veterans Administration Hospital

Palo Alto

Supported by a NIMH grant and the VA administration.

Source:

The Therapeutic Potential of Marijuana, 1976

Edited by Sidney Cohen and Richard C. Stillman

Plenum Medical Book Co, NY and London