"The Marijuana Conspiracy" and The Research Dodge

The Canadian film "The Marijuana Conspiracy," released in the US on 4/20, illustrates in part the absurdity and politicization of research into marijuana's effects. The film, based on a study that happened in 1972 in Toronto, begins with footage of politicians (all old, white men) railing against marijuana use. We then meet an old, white male addiction researcher downing a martini who hires an unscrupulous hippie-type researcher out for fame and fortune who recruits young women pot smokers for a study aimed at discovering marijuana's harms. 

The women were locked in a building for 98 days, with no escape to take a walk outside or see their friends or families, while being constantly observed by researchers. Even the joints they were given to smoke nightly couldn't counter the effects of this strange, unnatural setting and the film (and doubtlessly the study itself) devolves into melodrama. Like many rats put in a cage, the women were pointlessly overdosed with pot. Yet, they remained productive and experienced no ill effects, although some members of both the smoking group and the nonsmoking control groups had difficulty assimilating after their isolation. The results of the study were never publicized due to political reasons, and it took decades for Canada to finally legalize pot (the US still hasn't done so). 

Women Surpass Men Supporting Marijuana Legalization in New Poll

A new national poll from Quinnipiac University found a record high 69% of Americans support marijuana legalization, and that 70% of women support it, with only 68% of men surveyed in support.

This is the first time a poll has shown more support for legalization among women than men. Until very recently, women have consistently supported it 8-13% less than men. A Washington Post analysis of a 2013 Pew survey that found a 9% gap between men's and women's support concluded that women's religious beliefs and lower likelihood to use marijuana were at play, more so that motherhood or other factors.

A CBS poll released on 4/20/2016 was the first to show majority female support for marijuana legalization in the US. Though still trailing the 59% of men who were in favor, 54% of women then said they supported it too, up from only 43% of women and 54% of men in the previous year. A November 2020 Gallup poll found 69% of men and 66% of women supported legalization, narrowing the gender gap to 3%.

One reason for the shift is likely women's increased role in publicly advocating for legalization, many of them heading NORML chapters across the country. Women of all ages are also increasingly depicted using marijuana on film and TV and articles about legalization are more often picturing women, not just men. And women are feeling emboldened to speak up about their marijuana use (or at least admit to past use without apology, like VP Kamala Harris has).  

Photo: A supporter at the Pennsylvania Cannabis Festival in Kutztown, PA on April 17, 2021. Sean Simmers ssimmers@pennlive.com. 

UPDATE 11/23: The gender gap is back in the latest Gallup Poll, which shows a record 70% of Americans in favor of legalization, with 72% of men in support and only 68% of women. 

Sex Differences In Pain Relief with Cannabis

Photos by Larry Utley of a bipolar woman experiencing pain relief with cannabis.
Her face is shown pre-treatment (left) and at 30 and 60 seconds after smoking.

Less than 10% of neurological and pharmacological research is conducted on females in the US, says Dr. Rebecca Craft of Washington State University. Her lab is working to help correct that imbalance, by studying the effects of THC on male and female rats.

Craft's lab took healthy rats, 10 males and 10 females, and dosed them every 15 minutes with THC. At each dosage level, researchers did two tests for acute pain: putting the rats’ tails in 122-degree water and measuring how quickly they pulled their tails out; and applying pressure to their paws and measuring at what level of pressure they retracted their paws. As expected, the analgesic effect of THC increased at higher levels in both sexes, but to a greater extent in females.

Researchers then did a nine-day experiment, injecting the rats twice daily with THC in an amount determined to produce 80% of maximal analgesia (a lesser amount for females). The pain experiments were then repeated, in order to study to what extent tolerance to THC’s pain-relieving effects had taken place. It took more THC to show a pain-relieving response in rats that had received chronic doses, and this effect was also more pronounced in females.

Taken together with a recent study showing that women using cannabis daily reported a higher incidence of “abuse related effects” than men,  Dr. Craft’s work has been reported as being cautionary for women using cannabis medicinally. However Dr. Craft says that it’s hard to relate results, or doses, between acute pain studies in rodents and chronic pain in humans. For example, the opposite effect is found for morphine: male rats are more susceptible to its acute effects and develop greater tolerance, but the same sex difference has not been found in humans.

It’s been theorized that the hormone estradiol in menstruating females is responsible for the observed differences in cannabinoid effects, possibly through the mechanism of beta-arrestin2, an intracellular signaling molecule that interacts with the CB1 cannabinoid receptor in the brain. But some studies Craft’s lab has been working on indicate that sex hormones aren’t responsible for sex differences in tolerance to THC’s pain-relieving effects, although they may have a role in its sedative effects. Also, in rats a different enzyme metabolizes THC into its main active metabolite 11-OH-THC in males and females, but in humans, the enzyme is the same for both sexes.

Dr. Rebecca Craft of WSU

Dr. Craft’s next study will be working with a chronic pain model in rats, mimicking the inflammatory pain of rheumatoid arthritis. Chronic pain models in rodents have also been developed for neuropathic pain of the type experienced by chemotherapy patients and diabetes sufferers.

The work is important: women are more likely to present with chronic pain issues, for diseases like fibromyalgia, IBS, MS and migraine as well as the depression that comes with pain. A new study shows women find cannabis more effective than other pain-treatment modalities.

More human research is needed, Dr. Craft stresses, and also more research on females in both human and animal studies. The NIH has recently announced it will require sex-balancing in upcoming studies. Craft is encouraged by NIDA’s recent pronouncement that the agency will be providing more cannabis for research. Her work is funded by a NIDA grant.

Pointing to these developments, and to the legalization of medical and recreational marijuana that is happening across the US, Craft predicts, “We will see an explosion of information in the coming decades.”

Happy Women of Weed Day

Since I wrote a round-up of Famous Female Cannabis Connoisseurs in 2010, I’ve added a few notables to the list. Here they are, in honor of International Women's Day and Women's History Month.

After Elizabeth Taylor died, I googled and found a biography of her that said she smoked pot with Christopher Lawford. It’s interesting now because Lawford has joined with Kennedy cousin Patrick to start an organization aimed at forcing marijuana users into treatment. That the Kennedys would be considered expert on such a topic is, of course, laughable and lamentable. Watch a video of Liz smoking. 

For my Black Herstory posting last month, I decided to google Josephine Baker and sure enough, found evidence that she too had imbibed. (Baker is one of the women featured on the US government's Women's History Month website.)

Sadly, I added Teresa McGovern, daughter of the late Senator George McGovern, whose pot bust at the age of 18 helped turn her short life into a tragic one. Also, I found evidence that Lucille Armstrong, wife of trumpeter and mj enthusiast Louis Armstrong, was busted for carrying pot in 1954.

  

Lady Gaga smoked an enormous joint onstage, and she and Rhianna, who puffed pot in Hawaii and Tweets about it often, both dressed as “marijuana” on Halloween 2012. But it's Fiona Apple who's facing hashish charges in Texas. 

Lisa-Marie Presley expressed a desire to one day go off the grid and “become a big pothead.” VIP Laura Nyro was inducted into the Rock and Roll Hall of Fame, introduced by Bette Midler. Madonna smoked the SuperBowl halftime show and Amy Winehouse died of alcohol poisoning, causing many of her fans to wish she’d stuck to pot instead.

Lily Tomlin “outed” herself as a pot smoker on the cover of Culture magazine. Joan Rivers toked up on her reality show saying, back in the day she smoked it with Betty White, George Carlin, Woody Allen and Bill Cosby. Roseanne Barr appeared at Oaksterdam University while campaigning for President on the Peace & Freedom Party ticket.

Jane Fonda was caught puffing at a post-Oscar party in 2012. Heather Donahue of The Blair Witch Project released a book about growing medical marijuana in Northern California. Miss USA 2011 Alyssa Campanella said she supports medical marijuana; so does the reigning Miss Universe (although both say they're against recreational use). 

In fiction, secretary-turned-copywriter Peggy Olson puffed pot on Mad Men. Woody Allen’s Midnight in Paris depicted Alice B. Toklas and (possibly) Beatrice Hastings. Patti Smith’s award winning book Just Kids describes how she saw pot more as an aid to her work than a social drug. 

A video of Whoopi Goldberg surfaced in which she admits she was high when she picket up her Oscar for “Ghost.” Capping it off is Jennifer Lawrence, this year’s Oscar-winning Best Actress who, days later, was photographed smoking pot in Hawaii.